Centers for Disease Control predicts that diabetes will double by year 2025. By mere extrapolation it therefore stands to reason that diagnosis of Pancreatic cancer will also increase, albeit not by the same ratio. The incidence of cancer of the pancreas is far less funded when compared to other cancers such as breast, prostate, lung and colon just to name some of the more common ones.
What Is Pancreatic Cancer?
The pancreas is a gland organ that is located in the abdomen. It is part of the digestive system and produces important enzymes and hormones that help break down foods. The pancreas has an endocrine function because it releases juices directly into the bloodstream, and it has an exocrine function because it releases juices into ducts.
Enzymes, or digestive juices, produced by the pancreas are secreted into the small intestine to further break down food after it has left the stomach. The gland also produces the hormone insulin and secretes it into the bloodstream in order to regulate the body’s glucose or sugar level.
What Causes Pancreatic Cancer?
Cancer is ultimately the result of cells that uncontrollably grow and do not die. Normal cells in the body follow an orderly path of growth, division, and death. Programmed cell death is called apoptosis, and when this process breaks down, cancer results. Pancreatic cancer cells do not experience programmatic death, but instead continue to grow and divide. Although scientists do not know exactly what causes these cells to behave this way, they have identified several potential risk factors.
Genes – the DNA type.
Cells can experience uncontrolled growth if there is damage or mutations in the DNA, and therefore, damage to the genes involved in cell division.
Four key types of genes are responsible for the cell division process:
- Oncogenes tell cells when to divide.
- Tumor suppressor genes tell cells when not to divide.
- Suicide genes control apoptosis and tell cells to kill themselves if something goes wrong.
- DNA-repair genes instruct cells to repair damaged DNA.
Cancer occurs when a cell’s gene mutations make the cell unable to correct DNA damage and unable to commit suicide. Similarly, cancer is a result of mutations that inhibit oncogene and tumor suppressor gene functions, leading to uncontrollable cell growth.
- If you have DNA mutations of tumor suppressor genes that lead to pancreatic cancer, it is likely that the mutation was a result of factors that affected DNA after you were born rather than a result of inheritance from parents.
Genes – The Family Type.
Cancer can be the result of a genetic predisposition that is inherited from family members. It is possible to be born with certain genetic mutations or a fault in a gene that makes one statistically more likely to develop cancer later in life. However only about 10% of pancreatic cancers are though to be caused by inherited gene mutations. Genetic syndromes that are associated with pancreatic cancer include hereditary breast and ovarian cancer syndrome, melanoma, pancreatitis, and non-polyposis colorectal cancer (Lynch syndrome).
Traits, Habits, And DIET
Pancreatic cancers are more likely to exist in men than in women, and among African-Americans than among whites. Smoking cigarettes increases one’s risk of pancreatic cancer by a factor of 2 or 3. Even smokeless tobacco has been noted as a risk factor.
Diet and obesity have also been linked to cancers of the pancreas. People who do not exercise much and who are obese are more likely to develop pancreatic cancer. In addition, those who eat diets low in vegetables and fruits and high in red meat and fat are more likely to be diagnosed with the disease. Alcohol consumption is also considered a risk factor for pancreatic cancer. Long term, heavy drinking leads to chronic pancreatitis, which is a known risk factor for pancreatic cancer.
What Are The Symptoms Of Pancreatic Cancer?
- Pain in the upper abdomen from the tumor pushing against nerves.
- A painless yellowing of the skin and eyes and darkening of the urine called jaundice, created when the cancer interferes with the bile duct and the liver.
- Loss of appetite, nausea, and vomiting.
- Significant weight loss and weakness.
- Pale or grey stool and steatorrhea (excess fat in stool).
These symptoms of pancreatic cancer have numerous other causes, making it difficult to diagnose the disease before it is in an advanced stage.
Cancers of the pancreas are also associated with Trousseau’s sign – spontaneous blood clots formed in the portal blood vessels, deep veins of the arms and legs, or other superficial veins. Clinical depression is another symptom that is sometimes reported before the cancer is diagnosed.
If the cancer spreads, or metastasizes, additional symptoms can present themselves in the newly affected area. Symptoms of metastasis ultimately depend on the location to which the cancer has spread.
Islet cell or neuroendocrine cancers of the pancreas may cause the organ to produce too much insulin or hormones. This may lead to weak or dizzy feelings, chills, muscle spasms, or diarrhea.
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